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Buffalo Bills at San Francisco 49ers: Key Players, How to Watch, and Predictions-NFL round 13
The game will take place at Highmark Stadium in Orchard Park, New York, marking a key matchup as both teams aim to solidify their playoff positions in Week 13 of the NFL season​.

Key Players to Watch

Buffalo Bills

  1. Josh Allen (QB)

    The Bills' franchise quarterback is known for his dual-threat capabilities. Through 11 games in 2024, Allen has thrown for over 3,200 yards and 25 touchdowns while rushing for 400+ yards and 6 additional scores.

  2. Stefon Diggs (WR)

    Diggs remains Allen’s top target, with over 1,000 receiving yards and 9 touchdowns so far this season. His ability to create separation makes him a constant red-zone threat.

  3. Von Miller (EDGE)

    After returning from injury, Miller has been a disruptive force on defense with 7 sacks and numerous quarterback pressures.

San Francisco 49ers

  1. Brock Purdy (QB)

    The "Mr. Irrelevant"-turned-starter has kept the 49ers' offense efficient, throwing for 2,800+ yards and 22 touchdowns this season.

  2. Christian McCaffrey (RB)

    McCaffrey is a workhorse, with over 1,200 scrimmage yards and 12 total touchdowns. His versatility as a rusher and receiver makes him the centerpiece of the offense.

  3. Nick Bosa (EDGE)

    The reigning Defensive Player of the Year leads the 49ers’ pass rush with 10.5 sacks this season, consistently terrorizing opposing quarterbacks.

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Game Analysis

Buffalo Bills

The Bills are coming off a bye week (Week 12), giving them ample time to prepare and recover. They enter this game with a 7-4 record, needing a win to stay competitive in the AFC East. The offense ranks in the top 5 for both passing yards and points per game (28.2), but turnovers have been a recurring issue for Allen. Defensively, the Bills are strong against the pass but have struggled to contain the run, which could be problematic against McCaffrey.

San Francisco 49ers

The 49ers sit at 8-3 and lead the NFC West. Despite back-to-back losses before Week 13, they remain a top contender due to their balanced roster. Offensively, their quick passing game and play-action scheme will challenge the Bills’ linebackers. Defensively, the 49ers' elite pass rush must pressure Allen to limit explosive plays.

Key Matchups

  1. Bills’ Passing Attack vs. 49ers’ Secondary

    Stefon Diggs and Gabe Davis face a 49ers secondary that has been vulnerable to deep passes this season. Limiting big plays will be crucial for San Francisco.

  2. 49ers’ Ground Game vs. Bills’ Run Defense

    With Christian McCaffrey in the backfield, the 49ers can exploit Buffalo’s 19th-ranked rush defense.

  3. Nick Bosa vs. Buffalo’s Offensive Line

    Bosa's matchup with left tackle Dion Dawkins will be pivotal. Keeping Josh Allen upright is crucial for Buffalo’s success.

Predictions

  • Score Prediction: Bills 28, 49ers 24

    The Bills’ offensive firepower, combined with their home-field advantage, could prove too much for the 49ers despite San Francisco's balanced attack.

  • MVP Prediction: Josh Allen

    Look for Allen to shine under the bright lights, contributing both through the air and on the ground.

Learn more: NFL Week 13 - Full Schedule for Nov. 28 - Dec. 2 Games: Dates, Times, Key Matchups, Predictions

How to Watch

  • Date: Sunday, December 1, 2024
  • Time: 8:20 PM EST / 5:20 PM PST
  • Location: Highmark Stadium, Orchard Park, NY
  • TV Broadcast: NBC
  • Radio: WGR 550 (Bills), KNBR 680 AM (49ers)

Streaming Options:

  • Peacock (NBC streaming service)
  • NFL+ for mobile streaming
  • Sling TV, Hulu + Live TV, or YouTube TV with NBC access.

FAQs

  1. Who has the better record this season?

    The 49ers (8-3) currently have a better record than the Bills (7-4).

  2. What’s the weather forecast for the game?

    Cold temperatures around 30°F are expected at Highmark Stadium, potentially favoring the Bills.

  3. What is Buffalo’s historical record against San Francisco?

    The Bills lead the all-time series 7-6.

  4. Are there any notable injuries?

    Both teams are relatively healthy post-Week 12, but check the injury report closer to game day.

  5. What’s the biggest storyline for this matchup?

    It’s a clash of two Super Bowl hopefuls, with both teams looking to make a statement in prime time.

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